2.1 Crucial Dosage and Administration Recommendations Administer promethazine HCl and codeine phosphate oral Remedy by the oral route only. Always use an precise milliliter measuring gadget when administering promethazine HCl and codeine phosphate oral Alternative to ensure that the dose is calculated and administered properly.
If the individual develops these symptoms or symptoms, increase the dose to the past stage and taper much more little by little, either by increasing the interval concerning decreases, decreasing the level of adjust in dose, or both.
Effects about the Cardiovascular Program Codeine makes peripheral vasodilation which can cause orthostatic hypotension or syncope. Manifestations of histamine launch and/or peripheral vasodilation may well include things like pruritus, flushing, red eyes and sweating and/or orthostatic hypotension.
Most MAO inhibitors must also not be taken for two months just before treatment with this medication. Check with your health care provider when to get started on or cease getting this medication.
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Codeine Carcinogenicity scientific studies ended up executed with codeine. Two-calendar year experiments in F344/N rats and B6C3F1 mice were being conducted to evaluate the carcinogenic opportunity of codeine. No proof of tumorigenicity was noticed in male and feminine rats at codeine dietary doses nearly 70 and eighty mg/kg/working day (around equivalent to fifteen and twenty periods, the MRHD on a mg/m2 basis, respectively).
Codeine is changed into a robust opioid drug (morphine) in One's body. In a lot of people, this modification occurs faster plus much more wholly than common, which increases the chance of very serious side effects.
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Codeine Promethazine HCl and codeine phosphate oral Answer consists of codeine, a compound with a substantial likely for abuse much like other opioids which includes morphine and codeine.
Inform patients that a domestic teaspoon is just not an correct measuring system and these use may lead to overdosage and severe adverse reactions [see Overdosage (ten)]. For prescriptions the place a measuring gadget is not offered, a pharmacist can offer an acceptable calibrated measuring gadget and can offer Directions for measuring the proper dose.
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Before working with this medication, Ladies of childbearing age really should communicate with their medical professional(s) about the dangers and Positive aspects. Notify your doctor In case you are pregnant or Believe you might be pregnant. Through pregnancy, this medication isn't advised. It might marginally raise the threat of beginning defects if utilised in the course of the very first two months of pregnancy. Also, employing it for a long period or in superior doses near the anticipated supply date might harm the unborn child.
Disposal of Unused Promethazine HCl and Codeine Phosphate Oral Alternative Advise clients to correctly get rid of unused promethazine HCl and codeine phosphate oral Alternative. Advise sufferers to toss the drug within the residence trash following these measures. one) Take out them from their authentic containers and mix them with an undesirable material, which include utilized coffee grounds or kitty litter (this can make the drug fewer appealing to youngsters and pets, and unrecognizable to those who may perhaps deliberately go from the trash seeking medication).
Lifetime-Threatening Respiratory Depression Advise sufferers of the risk of website everyday living-threatening respiratory melancholy, which includes information that the danger is greatest when starting off promethazine HCl and codeine phosphate oral Resolution and that it may possibly arise even at suggested dosages [see Warnings and Precautions (5.